Editorial: Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects With Genomic Sciences

Analytical Sciences Editorial Board Members - Biographies.

Toxicogenomics in non-mammalian species—Editorial

In October 2004, the Organisation for Economic Co-operation and Development (OECD) and the International Programme on Chemical Safety (IPCS) organized a workshop in Kyoto Japan to outline the fundamental aspects and future directions of the then emerging science of “Toxicogenomics.” The output of this three-day meeting was summarized in the Report of the OECD/IPCS workshop on Toxicogenomics (OE...

Analytical approaches to genomic evolution.

We model the non-local mechanisms of genomic evolution and propose methods for studying the evolutionary divergence of species based on these models. Mechanisms include the movement of segments of genomes within a single chromosome (transpositions), the reciprocal translocation of segments between two chromosomes, and the inversion of segments. Each of these is studied in the context of a diffe...

Integrative genomic approaches to understanding cancer.

Further advances in the prevention, diagnosis and treatment of cancer require a more complete knowledge of the molecular mechanisms that program the malignant state. Until recently, identifying and validating genetic alterations in tumors that contribute to cancer involved painstaking efforts focused primarily on single mutations. However, the application of whole genome approaches to the study...

An integrative approach to genomic introgression mapping.

Near-isogenic lines (NILs) are valuable genetic resources for many crop species, including soybean (Glycine max). The development of new molecular platforms promises to accelerate the mapping of genetic introgressions in these materials. Here, we compare some existing and emerging methodologies for genetic introgression mapping: single-feature polymorphism analysis, Illumina GoldenGate single n...